Journal Covers

Cells Tissues Organs. Volume 202, Issue 1-2. Published 2016.
ACS Chemical Neuroscience. Volume 6, Issue 11. Published 2015.
Extracellular Matrix. Published 2015. 
Tissue Engineering Part C: Methods. Volume 16, Issue 2. Published 2010.
Journal of Neural Engineering. Volume 6, Issue 1. Published 2008.

Utility Patents

  • Application Number 15766585 - Controlled drug release from electrospun fibers. 2018.

  • Application Number 15731789 - Superparamagnetic particle scaffold for regenerating damaged neural tissue. 2018.

  • Application Number 62041261 - In vitro culture model of anisotropic to isotropic transitions. 2014.

  • Application Number 62056013 - Nanocomposite scaffold for the in vitro isolation of cells. 2014.

Book Chapters

6. D'Amato, A.R., Ziemba, A.M., Johnson, C.D.L. Advances on the Use of Electrospun Fibers in the Central Nervous System. Electrofluidodynamic Technologies for Biomaterials and Medical Devices. In Producrtion (2018)

5. Zuidema J.M., Hyzinski-Garcia M.C., Mongin A.A., Gilbert R.J. Cultivation and imaging of astrocytes on protein-coated fluorescent topographies constructed from aligned PLLA electrospun fibers. Extracellular Matrix. Neuromethods Volume 93, 2015. Pp. 181-195. Editors: Elizabeth Powell and Jennie Leach.

4. McLane J.S., Schaub N.S., Gilbert R.J., Ligon L.A. "Electrospun nanofiber scaffolds for investigating cell-matrix adhesion” Adhesion Protein Protocols. Methods in Molecular Biology. V.1046, pp. 371-388. 2013. Editor: Amanda S. Coutts.

3. Simmons T.J., Rivet C.J., Singh G., Beaudet J., Sterner E., Guzman D., Hashim D.P., Lee S.H., Qian G., Lewis K.M., Rosales R., Karande P., Ajayan P.M., Gilbert R.J., Dordick J.S., Linhardt R.J.. “Applications of carbon nanotubes to wound healing biotechnology” Nanomaterials for Biomedicine. American Chemical Society. 2012. Editor: R. Nagarajan. Pages: 156-174.

2. Saxena, T., Gilbert, R. J., Pai, B. S. and Bellamkonda, R. V. 2011. Biomedical Strategies for Axonal Regeneration. eLS. Wiley Online Library.

1. Gilbert, R. J. and Bellamkonda, R. V. 2005. Regeneration of Nervous Tissue. eLS. Wiley Online Library.


54. Ziemba AM, D’Amato AR, MacEwen T, Puhl D, Koppes A, Koppes R, Lennartz M, Gilbert RJ. Stabilized IL-4-loaded PLGA films shift pro-inflammatory macrophages towards a regenerative phenotype in vitro. ACS Applied Bio Materials. Submitted (2018).

53. D’Amato AR, Puhl DL, Ziemba AM, Johnson CDL, Doedee J, Bao J, Gilbert RJ. Exploring the effects of electrospun fiber surface nanotopography on neurite outgrowth and branching in sensory neuron cultures. PLOS ONE. In Review (2018).

52. Zuidema JM, Gilbert RJ, Gottipati MJ. Biomaterial Approaches to Modulate Reactive Astroglial Response. Cells Tissues Organs. In Press (2018).

51. Johnson, C., Zuidema, J., Kearns, K., Maguire, A., Desmond, G., Thompson, D., Gilbert, R. The Effect of Electrospun Fiber Diameter on Astrocyte-Mediated Neurite Guidance and Protection. ACS Applied Bio Materials. In Press (2018).

50. Awada, H., Al Samad, A., Laurencin, D., Gilbert, R., Dumail, X., El Jundi, A., Bethry, A., Pomrenke, R., Johnson, C., Lemaire, L., Franconi, F., Larionova, J., Nottelet, B. Controlled Anchoring of Iron-Oxide Nanoparticles on Polymeric Nanofibers: Easy Access to Core-Shell Organic-Inorganic Nanocomposites for Magneto-Scaffolds. Submitted to ACS Applied Materials and Interfaces (2018).

49. McCleery, C., Kingsley, D., Johnson, C.D.L., Bramson, M.T.K., Rende, D., Gilbert, R., Corr, D. Multi-modal characterization of polymeric gels to determine the influence of testing method on observed elastic modulus. Journal of the Mechanical Behavior of Biomedical Materials. In review (2018).

48. D’Amato, A.R., Bramson, M.T.K., Puhl, D.L., Johnson, J., Corr, D.T., Gilbert R.J. Solvent Retention in Electrospun Fibers affects Scaffold Mechanical Properties. Electrospinning 2, 15-28 (2018).

47. Johnson, C.D.L., D’Amato, A.R., Puhl, D.L., Wich, D.M., Vespermann, A., Gilbert, R.J. Electrospun Fiber Surface Nanotopography Influences Astrocyte-Mediated Neurite Outgrowth. Biomedical Materials 13 (2018).

46. Ziemba, A.M., Lane, K.P., San Segundo, I.M., D’Amato, A.R., Mason, A.K., Sexton, R.J., Casajus, H., Gross, R.A., Corr, D.T., Gilbert, R.J. Poly-L-lactic acid-co-poly(pentadecalactone) electrospun fibers result in greater neurite outgrowth of chick dorsal root ganglia in vitro compared to poly-L-lactic acid fibers. ACS Biomaterials Science and Engineering. 1491-1497 (2018).

45. Johnson, CDL., Ganguly, D., Zuidema, J.M., Cardinal, T.J., Kearns, K.R., McCarthy, S.M., Thompson, D.M., Ramanath, G., Borca-Tasciuc, D-A., Dutz, S., Gilbert, R.J. Injectable, magnetically aligned electrospun fiber conduits for treatment of contusive nervous system injury. ACS Applied Materials and Interfaces. In Press (2018).

44. D'Amato, A., Schaub, N., Cardenas, J., Fiumara, A., Troiano, P., Fischetti, A., Gilbert, R.J. Removal of retained electrospinning solvent prolongs drug release from electrospun PLLA fibers. Polymer 123, 121-127 (2017).

43. Ganguly, D., Johnson, C., Gottipati, M.K., Rende, D., Borca-Tasciuc, D.A., Gilbert, R.J. Specific nanoporous geometries on anodized alumina surfaces influence astrocyte adhesion and GFAP immunoreactivity levels. ACS Biomaterials Science and Engineering 1, 128-141 (2017).

42. Ziemba, A.M. and Gilbert, R.J. Biomaterials for local, controlled drug delivery to the injured spinal cord. Frontiers in Pharmacology, 8:245, (2017).

41. Schaub, N.J., D'Amato, A.R., Mason, A., Corr, D.T., Harmon, E.Y., Lennartz, M.R., Gilbert, R.J. The effect of engineered nanotopography of electrospun microfibers on fiber rigidity and macrophage cytokine production. J Biomaterial Science, Polymer Edition 13, 1303-1323 (2017).

40. Ziemba, A.M., Gottipati, M., Totsingan, F., Hanes, C., Gross, R., Lennartz, M.R., Gilbert, R.J. Sophorolipid Butyl Ester Diacetate Does Not Affect Macrophage Polarization but Enhances Astrocytic Glial Fibrillary Acidic Protein Expression at Micromolar Concentrations in Vitro. ACS Chemical Neuroscience 8, 752-758 (2017).

39. D'Amato, A.R., Schaub, N.J., Cardenas, J.M., Franz, E., Ziemba, A.M., Gilbert, R.J. Evaluation of Procedures to Quantify Solvent Retention in Electrospun Fibers and Facilitate Solvent Removal. Fibers and Polymers 18, 483-492 (2017).

38. Gilbert, R.J. Engineering Approaches for Treatment of Spinal Cord Injuries. Cells Tissues Organs 202, 5 (2016).

37. Zuidema, J. M., Gilbert, R. J. & Osterhout, D. J. Nanoparticle Technologies in the Spinal Cord. Cells Tissues Organs 202, 102–115 (2016).

36. Koppes, A. N. et al. Robust neurite extension following exogenous electrical stimulation within single walled carbon nanotube-composite hydrogels. Acta Biomater. 39, 34–43 (2016).

35. Johnson, C. D. L., D’Amato, A. R. & Gilbert, R. J. Electrospun Fibers for Drug Delivery after Spinal Cord Injury and the Effects of Drug Incorporation on Fiber Properties. Cells Tissues Organs 202, 116–135 (2016).

34. Sene, S. et al. Formulation of benzoxaborole drugs in PLLA: from materials preparation to in vitro release kinetics and cellular assays. J. Mater. Chem. B 4, 257–272 (2015).

33. Schaub, N. J., Johnson, C. D., Cooper, B. & Gilbert, R. J. Electrospun Fibers for Spinal Cord Injury Research and Regeneration. J. Neurotrauma (2015). doi:10.1089/neu.2015.4165

32. Zuidema, J. M., Provenza, C., Caliendo, T., Dutz, S. & Gilbert, R. J. Magnetic NGF-Releasing PLLA/Iron Oxide Nanoparticles Direct Extending Neurites and Preferentially Guide Neurites along Aligned Electrospun Microfibers. ACS Chem. Neurosci. 6, 1781–1788 (2015).

31. Schaub, N. J. et al. The Effect of Surface Modification of Aligned Poly-L-Lactic Acid Electrospun Fibers on Fiber Degradation and Neurite Extension: e0136780. PLoS One 10, (2015).

30. Sambandamoorthy, S. et al. Matrix compliance and the regulation of cytokinesis. Biol. Open 4, 885–892 (2015).

29. Rivet, C. J., Zhou, K., Gilbert, R. J., Finkelstein, D. I. & Forsythe, J. S. Cell infiltration into a 3D electrospun fiber and hydrogel hybrid scaffold implanted in the brain. Biomatter 5, (2015).

28. Zuidema, J. M. et al. Nebulized solvent ablation of aligned PLLA fibers for the study of neurite response to anisotropic-to-isotropic fiber/film transition (AFFT) boundaries in astrocyte–neuron co-cultures. Biomaterials 46, 82–94 (2015).

27. Singh, A. V. et al. Astrocytes Increase ATP Exocytosis Mediated Calcium Signaling in Response to Microgroove Structures. Sci. Rep. 5, 7847 (2015).

26. Schaub, N. J., Rende, D., Yuan, Y., Gilbert, R. J. & Borca-Tasciuc, D.-A. Reduced Astrocyte Viability at Physiological Temperatures from Magnetically Activated Iron Oxide Nanoparticles. Chem. Res. Toxicol. 27, 2023–2035 (2014).

25. McLane, J. S., Rivet, C. J., Gilbert, R. J. & Ligon, L. A. A biomaterial model of tumor stromal microenvironment promotes mesenchymal morphology but not epithelial to mesenchymal transition in epithelial cells. Acta Biomater. 10, 4811–4821 (2014).

24. Zuidema, J. M., Rivet, C. J., Gilbert, R. J. & Morrison, F. A. A protocol for rheological characterization of hydrogels for tissue engineering strategies. J. Biomed. Mater. Res. B Appl. Biomater. 102, 1063–1073 (2014).

23. McKay, C. A. & Gilbert, R. J. Design of hydrogel biomaterial interfaces for the injured spinal cord. Surf. Innov. 2, 26–46 (2014).

22. Rivet, C. J., Yuan, Y., Gilbert, R. J. & Borca-Tasciuc, D.-A. Effect of magnetic nanoparticle heating on cortical neuron viability. Int. J. Hyperthermia 30, 79–85 (2014).

21. McKay, C. A. et al. An Injectable, Calcium Responsive Composite Hydrogel for the Treatment of Acute Spinal Cord Injury. ACS Appl. Mater. Interfaces 6, 1424–1438 (2014).

20. Zuidema, J. M. et al. Enhanced GLT-1 mediated glutamate uptake and migration of primary astrocytes directed by fibronectin-coated electrospun poly-l-lactic acid fibers. Biomaterials 35, 1439–1449 (2014).

19. Koppes, A. N. et al. Neurite outgrowth on electrospun PLLA fibers is enhanced by exogenous electrical stimulation. J. Neural Eng. 11, 046002 (2014).

18. Schaub, N. J., Britton, T., Rajachar, R. & Gilbert, R. J. Engineered Nanotopography on Electrospun PLLA Microfibers Modifies RAW 264.7 Cell Response. ACS Appl. Mater. Interfaces 5, 10173–10184 (2013).

17. Schaub, N. J., Kirkpatrick, S. J. & Gilbert, R. J. Automated Methods to Determine Electrospun Fiber Alignment and Diameter Using the Radon Transform. BioNanoScience 3, 329–342 (2013).

16. Pandit, V. et al. Evaluation of Multifunctional Polysaccharide Hydrogels with Varying Stiffness for Bone Tissue Engineering. Tissue Eng. Part A 19, 2452–2463 (2013).

15. Roberts, M. A., Mendez, U., Gilbert, R. J., Keim, A. P. & Goldman, J. Increased Hyaluronan Expression at Distinct Time Points in Acute Lymphedema. Lymphat. Res. Biol. 10, 122–128 (2012).

14. Rivet, C. J., Yuan, Y., Borca-Tasciuc, D.-A. & Gilbert, R. J. Altering Iron Oxide Nanoparticle Surface Properties Induce Cortical Neuron Cytotoxicity. Chem. Res. Toxicol. 25, 153–161 (2012).

13. Hurtado, A. et al. Robust CNS regeneration after complete spinal cord transection using aligned poly-l-lactic acid microfibers. Biomaterials 32, 6068–6079 (2011).

12. Zuidema, J. M., Pap, M. M., Jaroch, D. B., Morrison, F. A. & Gilbert, R. J. Fabrication and characterization of tunable polysaccharide hydrogel blends for neural repair. Acta Biomater. 7, 1634–1643 (2011).

11. Bouta, E. M. et al. Biomaterial guides for lymphatic endothelial cell alignment and migration. Acta Biomater. 7, 1104–1113 (2011).

10. Schaub, N. J. & Gilbert, R. J. Controlled release of 6-aminonicotinamide from aligned, electrospun fibers alters astrocyte metabolism and dorsal root ganglia neurite outgrowth. J. Neural Eng. 8, 046026 (2011).

9. Gilbert, R. J., Rivet, C. J., Zuidema, J. M. & Popovich, P. G. Biomaterial Design Considerations for Repairing the Injured Spinal Cord. Crit. Rev. Biomed. Eng. 39, (2011).

8. Cregg, J.M., Wiseman, S.L., Pietrzak, N.M., Smith, M.R., Jaroch, D.B., Clupper, D.C., Gilbert, R.J. A rapid, quantitative method for assessing axonal extension on biomaterial platforms. Tissue Eng Part C Methods. 16, 167-172 (2010).

7. Wang, H. B., Mullins, M. E., Cregg, J. M., McCarthy, C. W. & Gilbert, R. J. Varying the diameter of aligned electrospun fibers alters neurite outgrowth and Schwann cell migration. Acta Biomater. 6, 2970–2978 (2010).

6. Cao, Z., Gilbert, R. J. & He, W. Simple Agarose−Chitosan Gel Composite System for Enhanced Neuronal Growth in Three Dimensions. Biomacromolecules 10, 2954–2959 (2009).

5. Delvaux, A.B., Trombley, M.T., Rivet, C.J., Dykla, J.J., Jensen, D., Smith, M.R., Gilbert, R.J. Design and development of a cardiopulmonary resuscitation mattress. J Intensive Care Med. 24, 195-199 (2009).

4. Wang, H.B., Mullins, M.E., Cregg, J.M., Hurtado, A., Oudega, M., Trombley, M.T., Gilbert, R.J. Creation of highly aligned electrospun poly-L-lactic acid fiers for nerve regeneration applications. J. Neural Eng. 6,016001 (2009).

3. Martin, B. C., Minner, E. J., Wiseman, S. L., Klank, R. L. & Gilbert, R. J. Agarose and methylcellulose hydrogel blends for nerve regeneration applications. J. Neural Eng. 5, 221 (2008).

2. Gilbert, R. J. et al. CS-4,6 is differentially upregulated in glial scar and is a potent inhibitor of neurite extension. Mol. Cell. Neurosci. 29, 545–558 (2005).

1. Zhong, Y., Yu, X., Gilbert, R. & Bellamkonda, R. V. Stabilizing electrode-host interfaces: A tissue engineering approach. J. Rehabil. Res. Dev. 38, 627–32 (2001).